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The painting itself is a copy of Brodero Matthisen's portrait of Stefan Czarniecki. The portrayed man has a face of Maciej Miąsik, Chief Production Manager of The Witcher.
In several houses player can see a portrait of a man clad in red clothes and holding a golden mace. In-game bestiaries, " The Tome of Fear and Loathing, volume I" and volume II, are possibly allusions to Fear and Loathing in Las Vegas by Hunter S. In-game PFI might rather be a reference to the Witcher saga.) (There is also a reference to the Poor Fucking Infantry in the Witcher saga books, at least in Polish and Czech version. PFI reference from one of the guards near the gates of Old Vizima in Chapter II, and " Poor Fucking Infantry" graffiti on recruiting poster in Temple quarter. An advertisement in the Trade Quarter for a two hand axe: " The Terminator". The sword called Illegal Sword looks like the bone sword from the movie Brotherhood of the Wolf.
King Foltest has the face of Michael Wincott (interpreting Top Dollar in The Crow and Rochefort in The Three Muskeeters). Roderick de Wett has the face of Tomasz Gop, a Senior Producer at CD Projekt RED. Siegfried of Denesle has the face of Konrad Tomaszkiewicz a designer at CD Projekt RED.
You can see him in a video called "Making of Combat 2" on the official site.
Detective Raymond has the face of a head artist on The Witcher Team - Adam Badowski. It seems that the disposal of the ten Monoliths on the map of the Swamp corresponds to the diagram of the Tree of Life, a common symbol in the Jewish Kabbalàh.
The visual concept of the Swamp cemetery (the ruined church with the bald spectral trees) resembles a famous 19th century gothic painting The Abbey in the Oakwood by the German painter Caspar David Friedrich. The third fresco in the dining hall of Kaer Morhen is very reminiscent of a Gustave Moreau painting. This painting features a man in a pose identical to the sculpture of Laocoön and His Sons, battling with snakes. Geralt says "Witchers are better with a sword than a paintbrush" when he approaches it. On the other side of the doorway from 'Witcher George' is another painting with serpents. George is often depicted in Eastern Orthodox Church iconography. A "monster slayer" on a horse killing a scaly beast. In Kaer Morhen on the ground floor, there is a picture on the wall on which Geralt will comment with "Witcher George slaying the dragon." which shows striking similarities to Paolo Uccello's Saint George and the Dragon. In some of the houses and locations there is a picture hanging about of Leonardo da Vinci (at least it looks very much like him). Some players feel that the runes on a sword tempered with temporary runes spell silentrun with what seems to be the futhark-based runic alphabet from Ultima.